Ehrlich, Paul

Ehrlich, Paul
SUBJECT AREA: Medical technology
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b. 14 March 1854 Strehlen, Silesia, Germany
d. 20 August 1915 Homburg, Saarland, Germany
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German medical scientist who laid the foundations of intra-vital staining in histology, and of chemotherapy.
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After studying medicine at a number of schools in Germany, Ehrlich graduated from Leipzig in 1878. After some years at the Charite in Berlin, an attack of tuberculosis compelled a three-year sojourn in Egypt for treatment. Upon his return in 1890, he was invited by Koch to work at the new Institute for Infectious Diseases. There he commenced his work on immunity, having already, while a student, discovered the mast cells in the blood (1877) and then developed the techniques of differential staining which identified the other white cells of the blood. In 1882 he established the diazo reaction in the urine of typhoid patients, and in the same year he identified the acid-fast staining reactions of the tubercle bacillus. He then moved to the study of immunity in infectious disease, which led him to the search for synthetic chemical substances which would act on the causative organism without harming the patient's tissue. The outcome of his specific investigation of syphilis was the discovery of the first two specific chemotherapeutic agents: salvarsan (being the 606th compound to be tested); and the later, but less toxic, neosalvarsan (the 909th). In 1896 he became Director of the State Institute for Serum Research, and in 1906 Director of the new Royal Institute for Experimental Therapy at Frankfurt-am-Main. He received numerous awards and honours from governments and learned societies.
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Principal Honours and Distinctions
Nobel Prize for Medicine or Physiology (jointly with E.Metchnikov) 1908.
Bibliography
1879, "Beiträge für Kentnis der granulierten Bindegewabszellen und der Eosinophilen Leucocythen" Arch. Anat. Physiol. Abt.
1914, Paul Ehrlich: eine Darstellung seines wissenschaftlichen Wirkens, Festschrift zum
60. Geburtstage des Forschers.
Further Reading
M.Marquardt, 1924, Paul Ehrlich als Mensch und Arbeiter.
MG

Biographical history of technology. - Taylor & Francis e-Librar. . 2005.

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  • Ehrlich, Paul R(alph) — (n. 29 may. 1932, Filadelfia, Pa., EE.UU.). Biólogo estadounidense. Estudió en la Universidad de Kansas y fue docente en la Universidad de Stanford desde 1959. Aunque gran parte de su investigación la hizo en entomología, se interesó sobre todo… …   Enciclopedia Universal

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